Late Consequences of Acute Ischemic Injury to a Solitary Kidney

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Late consequences of acute ischemic injury to a solitary kidney.

The sequelae of acute ischemic injury to a solitary kidney were assessed in rats subjected to right nephrectomy and transient occlusion of the left renal artery; control rats underwent right nephrectomy alone. Incomplete recovery from ischemic injury at 2 wk (serum creatinine levels of 1.1 +/- 0.2 versus 0.5 +/- 0.1 mg/dl, P < 0.05 for ischemia versus control) was followed by deterioration of r...

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Objective(s): Renal ischemia-reperfusion injury (IRI) as a severe condition of acute kidney injury (AKI) is the most common clinical problem with high mortality rates of 35-60% deaths in hospital. Mesenchymal stem cells (MSC) due to unique regenerative characteristics are ideal candidates for the treatment of the ischemic injuries. This work is focused on the administration of MSC to IRI-induce...

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ژورنال

عنوان ژورنال: Journal of the American Society of Nephrology

سال: 1999

ISSN: 1046-6673,1533-3450

DOI: 10.1681/asn.v102366